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๐ŸŒฟ Herbal Medicine Compendium

๐ŸŸข Milk Thistle (Silybum marianum)

Monograph ยท Reviewed August 2026
PH
Herbal Monograph Team ยท Botanical evidence reviewers
๐Ÿ“ Last reviewed: August 2026
โœ” Transparent sourcing ยท Some articles are AI-drafted, then reviewed & fact-checked by our team

In short: Milk Thistle (Silybum marianum) contains Silymarin (silibinin) and is traditionally used for liver support, antioxidant protection. Good safety profile; benefits for liver enzymes in some liver conditions are supported by trials, but evidence for liver-disease outcomes is mixed. It is not a treatment for any condition โ€” this page is general wellness information, not medical advice.

Active compoundsSilymarin (silibinin)
Common usesLiver support, Antioxidant protection
PreparationCapsules: 140 mg silymarin (standardised 70-80%) 2-3ร—/day with meals. Tea: seeds steeped 15 min.
Safety dosage420-600 mg/day of standardised silymarin in divided doses.
Evidence rating: Good safety profile; benefits for liver enzymes in some liver conditions are supported by trials, but evidence for liver-disease outcomes is mixed.
โš ๏ธ Contraindications & interactions: Generally well tolerated; mild laxative effect; rare allergy (Asteraceae); caution with diabetes medication (may lower glucose); not for pregnant women without supervision.

โ“ Questions about Milk Thistle (Silybum marianum)

What is Milk Thistle (Silybum marianum) used for? It is traditionally used for liver support, antioxidant protection. Traditional use is not the same as proven treatment.

How is Milk Thistle (Silybum marianum) prepared? Capsules: 140 mg silymarin (standardised 70-80%) 2-3ร—/day with meals. Tea: seeds steeped 15 min.

What is a safe dose of Milk Thistle (Silybum marianum)? 420-600 mg/day of standardised silymarin in divided doses.

What does the evidence say about Milk Thistle (Silybum marianum)? Good safety profile; benefits for liver enzymes in some liver conditions are supported by trials, but evidence for liver-disease outcomes is mixed.

Who should avoid Milk Thistle (Silybum marianum)? Generally well tolerated; mild laxative effect; rare allergy (Asteraceae); caution with diabetes medication (may lower glucose); not for pregnant women without supervision.

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